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Lynch Syndrome

Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is an inherited condition that causes increased risk for colon, endometrial (uterine), and other cancers. Lynch syndrome accounts for approximately 1-6% of all colorectal and endometrial cancers. Although not everyone with Lynch syndrome will get cancer, having this condition significantly increases the risk to develop certain cancers.

Features of the condition

• Colorectal cancer
• Endometrial cancer
• Ovarian cancer
• Stomach cancer
• Urinary tract/kidney cancer
• Small bowel cancer
• Brain cancer

Risk Factors

• Colorectal or endometrial tumor that tests positive indicating a high risk for Lynch syndrome
• Lynch cancer diagnosed under age 50
• Individual who has been diagnosed with more than one Lynch cancer (or diagnosed with a Lynch cancer more than once)
• Multiple family members diagnosed with a Lynch cancer

Genetic Tests

The following genetic tests may be appropriate based on your personal and/or family history:

• MLH1
• MSH2
• MSH6
• PMS2

Schedule an Appointment

To speak with a board-certified genetic counselor about your risks for this disease:

• Schedule genetic counseling appointment online
• Or call 1-800-975-4819
• Send email

Learn More

National Institutes of Health Genetics Home Reference(NIH/GHR)

John’s Hopkins Guide for Patients and Families

American Society of Clinical Oncology

National Cancer Institute (NCI)