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Hereditary breast and ovarian cancer syndrome

Hereditary breast and ovarian cancer syndrome (HBOC) is caused by inherited mutations in the BRCA1 and BRCA2 genes. Although not everyone with HBOC will get cancer, having this condition significantly increases the risk to develop certain cancers.

Features of the condition

• breast cancer
• ovarian cancer
• male breast cancer

Risk Factors

• Family history of breast or ovarian cancer
• Early onset breast cancer
• Cancer in both breasts
• Multiple family members with breast and/or ovarian cancer
• Breast and ovarian cancer in a single individual
• Male breast cancer
• Ashkenazi (Eastern European) Jewish ancestry
• Genetic mutations (see below)

Genetic Tests

The following genetic tests may be appropriate based on your personal and/or family history:

• BRCA1/2

Schedule an Appointment

To speak with a board-certified genetic counselor about your risks for this disease:

• Schedule genetic counseling appointment online
• Or call 1-800-975-4819
• Send email

Learn More

National Institutes of Health Genetics Home Reference(NIH/GHR)

American Society of Clinical Oncology

Support Groups

Be Bright Pink

FORCE

Sharsheret

Susan G. Komen