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Peutz-Jeghers syndrome

Peutz-Jeghers syndrome (PJS) causes growths called hamartomatous polyps in the gastrointestinal tract (particularly the stomach and intestines).  People with PJS also have a greatly increased risk of developing certain types of cancer.

Features of the condition

• Gastrointestinal polyps
• Dark skin coloration around the mouth, eyes, and nose; develops in early childhood and usually fades after puberty
• Tumors of the ovaries and testes
• Gastrointestinal cancers
• Breast cancer

Genetic Tests

The following genetic tests may be appropriate based on your personal and/or family history:

• STK11

Schedule an Appointment

To speak with a board-certified genetic counselor about your risks for this disease:

• Schedule genetic counseling appointment online
• Or call 1-800-975-4819
• Send email

Learn More

National Institutes of Health Genetics Home Reference(NIH/GHR)

American Society of Clinical Oncology